Piperine is a natural compound found in black pepper, and turmeric is a spice that contains curcumin. When used together, piperine and turmeric may have pharmacological benefits due to their synergistic effects.

The primary benefit of using piperine and turmeric together is their ability to increase the bioavailability of curcumin. Curcumin is a potent antioxidant and anti-inflammatory compound found in turmeric, but it has poor bioavailability on its own. Piperine, on the other hand, can increase the bioavailability of curcumin by inhibiting certain enzymes in the liver and intestines that break down curcumin.

Studies have shown that the combination of piperine and turmeric can increase the absorption of curcumin by up to 2000%, making it more effective at reducing inflammation, protecting against oxidative stress, and supporting overall health. Additionally, the combination has been shown to improve brain function, lower cholesterol levels, and reduce the risk of certain cancers.

In summary, the pharmacological benefits of using piperine and turmeric together include increased bioavailability of curcumin, which may lead to improved anti-inflammatory, antioxidant, and other health benefits. However, as with any supplement or medication, it is important to consult with a healthcare professional before use.

These statements regarding the pharmacological benefits of using piperine and turmeric together are supported by various studies and research articles. Here are the sources that provide more information on this topic:

  1. Prasad, Sahdeo et al. “Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine.” In Herbal Medicine, edited by Iris F. F. Benzie and Sissi Wachtel-Galor, 149-75. CRC Press, 2011.
  2. Shoba, Guido et al. “Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers.” Planta Medica 64, no. 4 (1998): 353-6.
  3. Jurenka, Julie S. “Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma longa: A Review of Preclinical and Clinical Research.” Alternative Medicine Review 14, no. 2 (2009): 141-53.
  4. Ghosh, Subhajit et al. “Piperine and Its Role in Chronic Diseases.” Advances in Experimental Medicine and Biology 928 (2016): 173-84.
  5. Aggarwal, Bharat B. et al. “Curcumin-Free Turmeric Exhibits Anti-Inflammatory and Anticancer Activities: Identification of Novel Components of Turmeric.” Molecular Nutrition & Food Research 57, no. 9 (2013): 1529-42.
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/

These sources provide evidence for the benefits of piperine and turmeric, as well as the mechanisms through which they work. It is important to note that the research in this field is ongoing, and new findings may emerge in the future.


*These statements have not been reviewed and evaluated by the FDA. Please consult with your healthcare provider for healthcare related guidance.

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